Angry Robot Books has opened for non-agented novel submissions until the end of the year. They looking for sci-fi, fantasy, and WTF. You can find the call here, be sure to check out the submission guidelines before submitting.
Crime fiction writers will want to keep an eye on Exhibit A Books a sister imprint of Angry Robot as they have mentioned in their guidelines that they will have an open reading period at some point also. Something to consider.